Искусственный интеллект придумал препарат, который борется с устойчивыми к антибиотикам бактериями

Ученые из Ставропольского медуниверситета применили нейросети и искусственный интеллект, чтобы на основе природных антимикробных пептидов разработать синтетический.  Он призван бороться с бактериями, и может применяться в качестве альтернативы антибиотикам.

Сгенерированные соединения представляют собой аминокислотную цепочку. Изначально специалисты изучили более трех тысяч таких цепочек, чтобы обнаружить в них закономерности. Затем нейросеть создала 200 уникальных пептидов. После серии жёстких отборов ученые выявили два вещества, способных вызвать полную гибель патогенных микроорганизмов на исследованиях в пробирке. При этом часть «нерабочих» молекул также показала положительный результат в опытах с лабораторными мышами. Один из препаратов, который был эффективен в культуре, повысил выживаемость подопытных на 50 процентов, а «нерабочий» — на 70 процентов.

Авторы разработки рассказали, что будут подаваться на гранты «Сколково», чтобы создать стартап.

«В нашем случае нейросеть сгенерировала уникальные вещества с выраженной антибактериальной активностью. Мы считаем, что данный метод можно применить и для разработки других соединений пептидной природы, а потому поставили перед собой амбициозную задачу — коммерциализировать технологию», — рассказал автор работы Альберт Болатчиев.



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